JavaScript Job: Structure Elucidation Expert, with focus on Mass S

Who we are:

At Roche, we believe there is an urgent need to deliver medical solutions now - even as we develop innovations for the future. We are passionately committed to changing patients' lives, and we are fearless in our decisions and actions. We also believe that good business means a better world. That's why we come to work every day. We are committed to scientific rigor, unassailable ethics and access to medical innovation for all. We do this today to build a better future.

Global Technical Development (PTD) is an organization of over two thousand people globally that are integral for the mission of Roche to develop meaningful medicines for patients. Therefore, PTD actively collaborates and develops creative technical solutions to bridge early-stage, late-stage and commercial product needs. The mandate of the group is to reliably deliver the pipeline and supply quality products to patients. The group excels in its work through innovation, teamwork, dedication, and mutual respect and contributes every single day, continuously improving what it does.

The Analytical Research & Development department (PTDC-A) is part of Global Technical Development (PTD) and responsible for analyzing drug substances and dosage forms of synthetic molecule development products. The ultimate goal of our work is a robust control strategy to release pharmaceutical products for clinical trials, and finally for commercial supply.

The “Hyphenated & Special Technologies (HST)” section provides key scientific customer support with Mass Spectrometry (MS), separation sciences and innovative special technologies. More than 20 mass spectrometry experts in HST verify the safety and quality of our synthetic drug substances and drug products by identity testing, characterization and quantification of any type of impurities.

Structure elucidation of small organic molecules and oligonucleotides is of paramount importance to help understand synthesis processes, degradation pathways or other factors that affect product quality. In many cases, high-performance liquid chromatography coupled to high-resolution tandem mass spectrometry (LC-HRMS/MS) is the method of choice to obtain detailed information about impurities in drug substance or drug product samples quickly - often with the help of sophisticated software tools.

As a structure elucidation expert in HST you are mainly responsible for the following tasks:

• Structure elucidation of unknown impurities in samples (e.g. small molecules, oligonucleotides, peptides or proteins) from e.g. process development, forced degradation studies, troubleshooting, etc.

• Qualitative LC-high-resolution MS, 2D-LC-high-resolution MS and GC-high resolution MS analytics of impurities in drug substances and drug products

• Evaluation and documentation of results in English

• Proactive and continuous improvement of work processes

• Working self-organized in a team of highly skilled and engaged colleagues

• Direct communication to stakeholders and customers in close collaboration with the project lead

• Writing and reviewing of reports

• Contribution to cross-sectional analytical projects

Who you are:

As a suitable candidate you bring an higher education (e.g. Bachelor or Master in natural science - chemistry, biochemistry, pharmacy, food chemistry or equivalent) or an apprenticeship as laboratory technician (or other degree such as DUT) with at least 5 years of work experience in the field of structure elucidation by LC-high-resolution MS. Work experience in GC-MS or NMR is an advantage.

Further qualifications are:

• You enjoy the structure elucidation of impurities and the interpretation of MS/MS spectra.

• You have hands-on experience in the development and optimization of analytical chromatographic and MS methods.

• Experience in the maintenance of chromatographic and MS instruments is an advantage.

• You are interested in digital transformation topics and IT applications (MS software, GeneData Expressionist®, Python, JavaScript etc.).

• You have a pragmatic, proactive and solution-oriented, independent and accurate workstyle.

• You are an excellent team player with good communication skills, open and curious and you are comfortable working with colleagues from various hierarchical levels in multiple departments.

• Very good knowledge of spoken and written English; basics of German are of advantage.

Your complete application includes a current CV and a Motivation Letter.

Have we triggered your interest? Apply now!

Roche embraces diversity and equal opportunity in a serious way. We are committed to building a team that represents a variety of backgrounds, perspectives, and skills. The more inclusive we are, the better our work will be.

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At Roche, more than 100,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we’ve become one of the world’s leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity.

Basel is the headquarters of the Roche Group and one of its most important centres of pharmaceutical research. Over 10,700 employees from over 100 countries come together at our Basel/Kaiseraugst site, which is one of Roche`s largest sites. Read more.

Besides extensive development and training opportunities, we offer flexible working options, 18 weeks of maternity leave and 10 weeks of gender independent partnership leave. Our employees also benefit from multiple services on site such as child-care facilities, medical services, restaurants and cafeterias, as well as various employee events.

We believe in the power of diversity and inclusion, and strive to identify and create opportunities that enable all people to bring their unique selves to Roche.

Roche is an Equal Opportunity Employer.